Thanks to the generative nature of the scheme, the segmentation method is robust to changes in MRI contrast or acquisition hardware. Using cross validation, we show that the algorithm can segment the structures in previously unseen T1 and FLAIR scans with great accuracy (mean error under 1 mm) and robustness (no failures in 383 scans including 168 AD cases).
Accurate automatic estimation of total intracranial volume→
/Compares various automated TIV-calculation routines to the "gold standard" of manual tracing. Freesurfer and SPM12 do well; SPM8 does poorly. Although the paper focuses on TIV, the results suggest SPM12 segmentation is better overall.
