Inter-individual variability in cortical excitability and motor network connectivity following rTMS

We found that non-responders (subjects not showing an MEP increase of ≥ 10% after one iTBS block) featured stronger rsFC between the stimulated primary motor cortex (M1) and premotor areas before stimulation compared to responders. However, only the group of responders showed increases in rsFC and MEPs, while most non-responders remained close to baseline levels after all three blocks of iTBS. Importantly, there was still a large amount of variability in both groups.