Take care of your health and relationships in addition to keeping perspective on science.
Take some risks. In your 60s and 70s, your biggest regrets are likely to be not about something you did, but about all the things you didn’t do, the opportunities you passed up. Faced with a "sensible" career risk, go for it. Grow from it. Some risks will fail. Some of mine certainly have. But you’ll be a wiser and better person for those failures, rather than someone who got stuck in a small world and was afraid to leave it.
